| Biography:
Steven Santana joined the Micro/Nanofluidics Laboratory in July of 2009. Steven completed his B.S. in Engineering at Harvey Mudd College, M.A. in Secondary Education at Loyola Marymount University, and an M.S. in Mechanical Engineering at Cornell University.
Following his time at Mudd, he worked as a math teacher in inner-city Los Angeles and as clinical faculty with the Loyola Marymount Center for Math and Science Teaching so as to prepare inner-city and underrepresented youth to successfully and confidently pursue undergraduate and graduate-level study in the fields of mathematics, science, and engineering. Steven continues to engage secondary students science and research.
At Cornell, Steven works on microfluidic devices for the capture and culture of circulating tumor cells.
Current Project: Circulating Tumor Cell Capture
My current research focuses on developing microfluidic devices to isolate and culture circulating tumor cells from cancer patient whole blood samples with a view toward evaluation of therapeutic efficacy and cancer progression, as well as uncovering of the biological foundations of metastasis. This work, an endeavor that combines microfluidics and tissue engineering, results in a platform that furthers cancer research and improves future clinical practice. My interests lie in both the engineering of these microdevices and the mechanisms of cancer biology they uncover.
Education:
- B.S. 2006, Harvey Mudd College, Claremont – Engineering, with Departmental Honors
- M.A. 2007, Loyola Marymount University, Los Angeles – Secondary Education
- M.S. 2012, Cornell University, Ithaca, NY – Mechanical Engineering
Awards and Honors:
- Alfred P. Sloan Fellow: 2009 – Present
- NSF GK-12 Fellow in Biomedical Engineering: 2010, 2011
- Honorable Mention, NSF: Graduate Research Fellowship Program: 2009, 2010
- Alpha Sigma Nu (Honor Society) member: 2008 – Present
- HMC Engineering Departmental Honors: 2006
- HMC Shirlynn Spacapan Memorial Scholar: 2005, 2006
- HMC Hale Chapin-Field Memorial Scholar: 2003, 2004, 2005
Publications:
- Steven M. Santana, He Liu, Neil H. Bander, Jason P. Gleghorn, Brian J. Kirby, “Immunocapture of Prostate Cancer Cells with Anti-PSMA Antibodies in Microdevices,” Biomedical Microdevices (2012); 14(2): 401-407. DOI: 10.1007/s10544-011-9616-5
- Brian J. Kirby, Mona Jodari, Matthew S. Loftus, Gunjan Gakhar, Erica D. Pratt, Chantal Chanel-Vos, Jason P. Gleghorn, Steven M. Santana, He Liu, James P. Smith, Vicente N. Navarro, Scott T. Tagawa, Neil H. Bander, David M. Nanus, Paraskevi Giannakakou ,”Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device,” PLoS ONE. (2012); 7(4): e35976. DOI: 10.1371/journal.pone.0035976
- James P. Smith, Alexander C. Barbati, Steven M. Santana, Jason P. Gleghorn, Brian J. Kirby, “Microfluidic Transport in Microdevices for Rare Cell Capture,” Electrophoresis (2012); 33(21), 3133-3142. DOI: 10.1002/elps.201200263
- Andrew D. Rhim, Fredrik I. Thege, Steven M. Santana, Timothy B. Lannin, Michael L. Kochman, Gregory G. Ginsberg, Vinay Chandrasekhara, Jeffrey A. Drebin, Yu-Xiao Yang, Anil K. Rustgi, Ben Z. Stanger, Brian J. Kirby, “Detection of Circulating Pancreas Cells in Patients with Pancreatic Cystic Lesions before Tumor Formation,” Manuscript in preparation (2012).
- Chao Huang, Steven M. Santana, He Liu, Neil H. Bander, Benjamin G. Hawkins, Brian J. Kirby, “Characterization of a hybrid dielectrophoresis-immunoaffinity cancer cell capture system,” Manuscript in preparation (2012).
Presentations:
- PSOC Symposium, New York, NY. Poster Presentation. “Capture and Interrogation of Circulating Tumor Cells in Tissue-Engineered Geometrically Enhanced Differential Immunocapture Microfluidic Devices,“ Fall 2012
- Society of Hispanic Professional Engineers Conference, Fort Worth, TX. Podium Presentation. “Capture and Interrogation of Circulating Tumor Cells in Tissue-Engineered GEDI Microfluidic Devices,” Fall 2012
- Biomedical Engineering Society Annual Meeting, Atlanta, GA. Poster Presentation. “Immunocapture of Circulating Tumor Cells in Tissue-Engineered GEDI Microdevices,” Fall 2012
- Annual Meeting for National Science Foundation GK-12 Project Teams, Washington, DC. Poster Presentation. “Circulating Tumor Cell Isolation and Analysis with GEDI Microdevices,” Spring 2012
- Second Annual PS-OC Network Investigators’ Meeting, La Jolla, CA. Poster Presentation. “Immunocapture and Release of Prostate Circulating Tumor Cells with Anti-PSMA Antibodies in Microfluidic Devices,” Spring 2011
- Northeast Bioengineering Conference, Troy, NY. Poster Presentation. “Immunocapture and Release of Prostate Circulating Tumor Cells with Anti-PSMA Antibodies in Microfluidic Devices,” Winter 2010
- Gordon Conference, New London, NH. Poster Presentation. “Tunable Composite Membranes for Gas Separation,” Summer 2006
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