I recently published a peer-reviewed article on “Cell capture simulations for the optimization of microfluidic rare cell immunocapture devices” in Biomedical Microdevices, along with my colleagues Tim Lannin, Yusef Syed, S Santana, and Brian Kirby. We detail a coupled computational fluid dynamics (CFD), particle advection, and experimentally-informed cell capture simulation to identify capture-optimized geometrically enhanced differential immunocapture (GEDI) designs. I show that it is possible to select a geometry which maximizes capture efficiency while rejecting small contaminating cells via infrequent collisions and large contaminating cells via high shear stress.
I attended and gave a talk at the Cornell NanoScale Facility (CNF) Annual Meeting 2013 in Ithaca, NY. My presentation was entitled “A Hybrid Dielectrophoresis and Immunocapture Microfluidic System for Enhanced Rare Cancer Cell Capture” and I also presented a poster on the same work. I really enjoyed catching up with old colleagues and meeting new ones at the conference… and all the delicious free food was nice too!
The CNF Annual Meeting brings together researchers at Cornell and neighboring institutions to present the latest innovations in micro- and nanoscale technologies. This year’s featured keynote speaker was Prof. Robert Austin from Princeton, who gave a great talk entitled “All Features Great and Small.”