Smith’s rare cell capture simulations published in Biomedical Microdevices

I recently published a peer-reviewed article on “Cell capture simulations for the optimization of microfluidic rare cell immunocapture devices” in Biomedical Microdevices, along with my colleagues Tim Lannin, Yusef Syed, S Santana, and Brian Kirby. We detail a coupled computational fluid dynamics (CFD), particle advection, and experimentally-informed cell capture simulation to identify capture-optimized geometrically enhanced differential immunocapture (GEDI) designs.  I show that it is possible to select a geometry which maximizes capture efficiency while rejecting small contaminating cells via infrequent collisions and large contaminating cells via high shear stress.

You can read the abstract and view a PDF on my website.